Nelson Jen An Chao, MD

  • Professor of Medicine
  • Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor
  • Professor in Immunology
  • Research Professor of Global Health
  • Professor in Pathology
  • Member of the Duke Cancer Institute
  • Chief, Division of Cell Therapy in the Department of Medicine
  • Affiliate of the Regeneration Next Initiative

https://medicine.duke.edu/faculty/nelson-jen-chao-md

Aside from these required disclosures chronic gastritis gastric cancer buy ditropan overnight delivery, your confidentiality will be protected by de-identifying the survey gastritis forum buy discount ditropan 5 mg. Costs and Compensation If you participate in the survey you will be entered into a random drawing to win $100 in Bean Bucks gastritis jugo de papa buy ditropan on line amex. He/she will be notified and the $100 in Bean Bucks will be applied to his/her account xenadrine gastritis discount ditropan master card. If you chose to withdraw from the study, you will not be eligible for consideration in the drawing. Click only after you have read all the information provided and your questions have been answered to your satisfaction. I was worried about situations in which I might panic and make a fool 0 1 2 3 of myself 7. I was aware of the action of my heart in the absence of physical 0 1 2 3 exertion. There is a special person with whom I 1 2 3 4 5 6 7 can share my joys and sorrows. Scoring Information: Total Scale: Sum across all 12 items, then divide by 12: 1 to 2. After you have your gall-bladder removed, following a lower fat, moderate fiber diet which consists of small frequent meals can be helpful to reduce diarrhea, gas and bloating. The guidelines below should help reduce the loose, watery bowel movements commonly reported after your gallbladder has been removed. By following the suggestions below, you should experience more normal bowel movements. It is important to realize these restrictions are only temporary, as you should be able to tolerate your typical diet within a few weeks after your surgery. Tips to minimize symptoms: fl Limit your fat intake o It is best to avoid greasy, fried or high fat foods and gravies for at least one week after surgery. A healthy meal would consist of lean protein with fruits, vegetables and whole grains. Interpreter / cultural needs Specific risks: fl Damage to large blood vessels causing bleeding. Yes No fl Damage to gut and/or bladder when the If Yes, is a qualified Interpreter presentfl Yes No fl Rarely, gas fed into the abdominal cavity can If Yes, is a Cultural Support Person presentfl The doctor has explained that you have the following fl Stones may be found outside the gall bladder. Surgical removal of the gall bladder using a fl Adhesions (bands of scar tissue) may form and laparoscope (a tube like instrument). During surgery an examination of the bile duct is fl An allergic reaction to the injected Contrast is required to look for gallstones. Risks of not having this procedure you have been taking blood thinning drugs such (Doctor to document in space provided. Continue in as Warfarin, Asprin, Clopidogrel (Plavix or Medical Record if necessary. Patient consent I request to have the procedure I acknowledge that the doctor has explained; Name of Patient. I understand Patients who lack capacity to provide consent the risks, including the risks that are specific to me. I have explained to the patient all the above points I have been given the following Patient under the Patient Consent section (G) and I am of Information Sheet/s: the opinion that the patient/substitute decisionAbout Your Anaesthetic maker has understood the information. The condition A telescope is passed into one of the small cuts to allow the surgeon to see inside the abdomen. Hollow the gall bladder is a small pear shaped organ that is metal tubes called ports are inserted into the other attached to the underside of the liver. The bile flows into the gut along a small tube the bile Carbon dioxide is blown into the abdomen to lift the duct. The surgeon puts instruments such as forceps and scissors into the other ports to help remove the gall bladder. The operation Metal clips are placed to block off the tube leading from the gall bladder to the other tubes (ducts) and the gall bladder and bile tubes the arteries leading to the gall bladder. Gall stones may form in the gall bladder and may cause pain, bloating, nausea and vomiting. The carbon dioxide gas Sometimes stones may travel into the bile duct and is allowed to escape before the small cuts are closed cause a blockage. If this occurs, the person may turn with staples or stitches yellow (jaundiced) and need urgent treatment. Sometimes during surgery an examination of the bile One in 5 people develop gall stones, although not duct is required to look for gallstones. However, those people Contrast medium is injected and x-rays are taken of who do have problems may go on to develop the bile duct. My anaesthetic bladder, inflammation of the pancreas and blockage of the bile duct causing jaundice and infection. If you have any concerns, discuss these Laparoscopic cholecystectomy is the surgical removal with your doctor. This is commonly known as key hole If you have not been given an information sheet, surgery. It is likely that complications will develop, making treatment more difficult and increasing the risks. The usual position of the cuts Page 1 of 3 Continues over page >>> Consent Information Patient Copy Cholecystectomy Laparoscopic 6. Alternative treatments Your lungs and blood supply Please note that some alternative treatments may not Take ten deep breaths every hour to move lung be available or suitable for everyone. At all costs, avoid smoking after surgery as this increases your Oral Dissolution Therapy risk of coughing (which is painful) and chest infection. Oral dissolution therapy is the taking of chemicals by It is very important after surgery that you start moving mouth to dissolve the gallstones. This helps prevent blood clots for patients who are not overweight, in a younger age forming in your legs and possibly going to your lungs. Exercise It has a 50% risk of gallstones recurring within 5 years You will feel tired for a few days after surgery. It takes about 14 days to recover and you fit enough to have surgery or who choose not to have should not drive during the first 7 days. The drugs may be poorly tolerated with heavy weights (more than 3-5 kilos) for at least two unpleasant side effects. Open Cholecystectomy this is to prevent a rupture where the cuts were Open cholecystectomy is surgical removal of the gall made and allow healing to take place inside. Drainage of the gall bladder along with stone removal is usually performed on patients who are too sick to fl Swollen abdomen. Recovery after your procedure fl Yellowing of your eyes and skin After the operation, the nursing staff will closely watch you until you have woken up. What are the general risks of this the ward to rest until you are ready to go home, procedurefl If you have any side effects There are risks and complications with this from the anaesthetic, such as headache, nausea, procedure. They include but are not limited to the vomiting, tell the nurse looking after you, who will give following. General risks: Pain fl Infection can occur, requiring antibiotics and You can expect to have pain in the abdomen. You may also have fl Bleeding could occur and may require a return to shoulder tip pain, caused by the gas used during the the operating room. Your you have been taking blood thinning drugs such pain should wear off within 4-5 days. Diet fl Small areas of the lung can collapse, increasing You may have a drip in your arm, this will come out the risk of chest infection. Wounds fl Heart attack or stroke could occur due to the You may have either clips or stitches and your strain on the heart. Page 2 of 3 Continues over page >>> Consent Information Patient Copy Cholecystectomy Laparoscopic 9.

Assessment of saccadic velocity may be of particular diagnostic use in parkinsonian syndromes gastritis morning nausea buy ditropan cheap. In progressive supranuclear palsy slowing of vertical saccades is an early sign (suggesting brainstem involvement; horizontal saccades may be affected later) biliary gastritis diet ditropan 2.5mg without a prescription, whereas vertical saccades are affected late (if at all) in corticobasal degeneration gastritis diet pdf buy 5 mg ditropan otc, in which condition increased saccade latency is the more typical nding eosinophilic gastritis elimination diet discount ditropan 2.5 mg without a prescription, perhaps reective of cortical involvement. Several types of saccadic intrusion are described, including ocular utter, opsoclonus, and square wave jerks. This is a late, unusual, but diagnostic feature of a spinal cord lesion, usually an intrinsic (intramedullary) lesion but sometimes an extramedullary compression. Spastic paraparesis below the level of the lesion due to corticospinal tract involvement is invariably present by this stage of sacral sparing. Sacral sparing is explained by the lamination of bres within the spinothalamic tract: ventrolateral bres (of sacral origin), the most external bres, are involved later than the dorsomedial bres (of cervical and thoracic origin) by an expanding central intramedullary lesion. Although sacral sparing is rare, sacral sensation should always be checked in any patient with a spastic paraparesis. The outstanding ability may be feats of memory (recalling names), calculation (especially calendar calculation), music, or artistic skills, often in the context of autism or pervasive developmental disorder. Scanning speech was originally considered a feature of cerebellar disease in multiple sclerosis (after Charcot), and the term is often used with this implication. Scanning speech correlates with midbrain lesions, often after recovery from prolonged coma. The examiner then places the tuning fork over his/her own mastoid, hence comparing bone conduction with that of the patient. If still audible to the examiner (presumed to have normal hearing), a sensorineural hearing loss is suspected, whereas in conductive hearing loss the test is normal. Mapping of the defect may be performed manually, by confrontation testing, or using an automated system. In addition to the peripheral eld, the central eld should also be tested, with the target object moved around the xation point. A central scotoma may be picked up in this way or a more complex defect such as a centrocaecal scotoma in which both the macula and the blind spot are involved. Infarction of the occipital pole will produce a central visual loss, as will optic nerve inammation. Scotomata may be absolute (no perception of form or light) or relative (preservation of form, loss of colour). A scotoma may be physiological, as in the blind spot or angioscotoma, or pathological, reecting disease anywhere along the visual pathway from retina and choroid to visual cortex. It has been claimed as a reliable test of posterior column function of the spinal cord. Errors in this test correlate with central conduction times and vibration perception threshold. The utility of testing tactile perception of direction of scratch as a sensitive clinical sign of posterior column dysfunction in spinal cord disorders. Seizure morphology may be helpful in establishing aetiology and/or focus of onset. Partial: simple (no impairment of consciousness), for example, jerking of one arm, which may spread sequentially to other body parts (Jacksonian march); or complex, in which there is impairment or loss of consciousness: may be associated with specic aura (olfactory, deja vu, jamais vu) and/or automatisms (motor. Otherwise, as for idiopathic generalized epilepsies, various antiepileptic medications are available. Best treated with psychological approaches or drug treatment of underlying affective disorders; antiepileptic medications are best avoided. The differentiation of epileptic from non-epileptic seizures may be difcult; it is sometimes helpful to see a video recording of the attacks or to undertake in-patient video-telemetry. This pattern is highly suggestive of a foramen magnum lesion, usually a tumour but sometimes demyelination or other intrinsic inammatory disorder, sequentially affecting the lamination of corticospinal bres in the medullary pyramids. Cross References Hemiparesis; Paresis; Quadriparesis, Quadriplegia Setting Sun Sign the setting sun sign, or sunset sign, consists of tonic downward deviation of the eyes with retraction of the upper eyelids exposing the sclera. Setting sun sign is a sign of dorsal midbrain compression in children with untreated hydrocephalus. Metallic poisonings (mercury, bismuth, lead) may also produce marked salivation (ptyalism). Recently, the use of intraparotid injections of botulinum toxin has been found useful. Botulinum toxin treatment of sialorrhoea: comparing different therapeutic preparations. Cross References Bulbar palsy; Parkinsonism Sighing Occasional deep involuntary sighs may occur in multiple system atrophy. Sighing is also a feature, along with yawning, of the early (diencephalic) stage of central herniation of the brainstem with an otherwise normal respiratory pattern. Recognition of single objects is preserved; this is likened to having a fragment or island of clear vision which may shift from region to region. There may be inability to localize stimuli even when they are seen, manifest as visual disorientation. Ventral simultanagnosia is most evident during reading which is severely impaired and empirically this may be the same impairment as seen in pure alexia; otherwise decits may not be evident, unlike dorsal simultanagnosia. This is thought to reect damage to otolith-ocular pathways or vestibulo-ocular pathways. Skew deviation has been associated with posterior fossa lesions, from midbrain to medulla. Ipsiversive skew deviation (ipsilateral eye lowermost) has been associated with caudal pontomedullary lesions, whereas contraversive skew (contralateral eye lowermost) occurs with rostral pontomesencephalic lesions, indicating that skew type has localizing value. Skew deviation with ocular torsion: a vestibular brainstem sign of topographic diagnostic value. Dysarthria, facial paresis, hemiparesis with or without hemihypoaesthesia, and excessive laughing with or without crying were common accompanying features in one series.

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Depersonalization is a very common symptom in the general population and may contribute to neurological presentations described as dizziness gastritis virus order ditropan 2.5 mg with visa, numbness treating gastritis diet order discount ditropan, and forgetfulness gastritis gluten cheap generic ditropan canada, with the broad differential diagnoses that such symptoms encompass gastritis diet 66 discount ditropan 5mg with mastercard. Such self-induced symptoms may occur in the context of meditation and self-suggestion. Cross References Derealization; Dissociation Derealization Derealization, a form of dissociation, is the experience of feeling that the world around is unreal. Cross References Alien hand, Alien limb; Intermanual conict Diamond on Quadriceps Sign Diamond on quadriceps sign may be seen in patients with dysferlinopathies (limb girdle muscular dystrophy type 2B, Miyoshi myopathy): with the knees slightly bent so that the quadriceps are in moderate action, an asymmetric diamondshaped bulge may be seen, with wasting above and below, indicative of the selectivity of the dystrophic process in these conditions. Cross Reference Calf head sign Diaphoresis Diaphoresis is sweating, either physiological as in sympathetic activation. Diaphoresis may be seen in syncope, delirium tremens, or may be induced by certain drugs. Anticholinergics decrease diaphoresis but increase core temperature, resulting in a warm dry patient. Forced vital capacity measured in the supine and sitting positions is often used to assess diaphragmatic function, a drop of 25% being taken as indicating diaphragmatic weakness. The spatial and temporal characteristics of the diplopia may help to ascertain its cause. Diplopia may be monocular, in which case ocular causes are most likely (although monocular diplopia may be cortical or functional in origin), or binocular, implying a divergence of the visual axes of the two eyes. With binocular diplopia, it is of great importance to ask the patient whether the images are separated horizontally, vertically, or obliquely (tilted), since this may indicate the extraocular muscle(s) most likely to be affected. Whether the two images are 108 Diplopia D separate or overlapping is important when trying to ascertain the direction of maximum diplopia. The effect of gaze direction on diplopia should always be sought, since images are most separated when looking in the direction of a paretic muscle. Conversely, diplopia resulting from the breakdown of a latent tendency for the visual axes to deviate (latent strabismus, squint) results in diplopia in all directions of gaze. Examination of the eye movements should include asking the patient to look at a target, such as a pen, in the various directions of gaze (versions) to ascertain where diplopia is maximum. Then, each eye may be alternately covered to try to demonstrate which of the two images is the false one, namely that from the non-xing eye. Manifest squints (heterotropia) are obvious but seldom a cause of diplopia if long-standing. Transient diplopia (minutes to hours) suggests the possibility of myasthenia gravis. Divergence of the visual axes or ophthalmoplegia without diplopia suggests a long-standing problem, such as amblyopia or chronic progressive external ophthalmoplegia. Cross References Motor neglect; Neglect Disc Swelling Swelling or oedema of the optic nerve head may be visualized by ophthalmoscopy. It produces haziness of the nerve bre layer obscuring the underlying vessels; there may also be haemorrhages and loss of spontaneous retinal venous pulsation. Disc swelling due to oedema must be distinguished from pseudopapilloedema, elevation of the optic disc not due to oedema, in which the nerve bre layer is clearly seen. The clinical history, visual acuity, and visual elds may help determine the cause of disc swelling. The disinhibited patient may be inappropriately jocular (witzelsucht), short-tempered (verbally abusive, physically aggressive), distractible (impaired attentional mechanisms), and show emotional lability. A Disinhibition Scale encompassing various domains (motor, intellectual, instinctive, affective, sensitive) has been described. Disinhibition is a feature of frontal lobe, particularly orbitofrontal, dysfunction. Cross References Attention; Emotionalism, Emotional lability; Frontal lobe syndromes; Witzelsucht Dissociated Sensory Loss Dissociated sensory loss refers to impairment of selected sensory modalities with preservation, or sparing, of others. Conversely, pathologies conned, largely or exclusively, to the dorsal columns (classically tabes dorsalis and subacute combined degeneration of the cord from vitamin B12 deciency, but probably most commonly seen with compressive cervical myelopathy) impair proprioception, sometimes sufcient to produce pseudoathetosis or sensory ataxia, whilst pain and temperature sensation is preserved. Small bre peripheral neuropathies may selectively affect the bres which transmit pain and temperature sensation, leading to a glove-and-stocking impairment to these modalities. Neuropathic (Charcot) joints and skin ulceration may occur in this situation; tendon reexes may be preserved. Common in psychiatric disorders (depression, anxiety, schizophrenia), these symptoms are also encountered in neurological conditions (epilepsy, migraine, presyncope), conditions such as functional weakness and non-epilpetic attacks, and in isolation by a signicant proportion of the general population. Symptoms of dizziness and blankness may well be the result of dissociative states rather than neurological disease. The superior division or ramus supplies the superior rectus and levator palpebrae superioris muscles; the inferior division or ramus supplies medial rectus, inferior rectus and inferior oblique muscles. Isolated dysfunction of these muscular groups allows diagnosis of a divisional palsy and suggests pathology at the superior orbital ssure or anterior cavernous sinus. However, occasionally this division may occur more proximally, at the fascicular level. Although this can be done in a conscious patient focusing on a visual target, smooth pursuit eye movements may compensate for head turning; hence the head impulse test (q. The manoeuvre is easier to do in the unconscious patient, when testing for the integrity of brainstem reexes. In many elderly people the extensor tendons are prominent in the absence of signicant muscle wasting. Cross Reference Wasting Double Elevator Palsy this name has been given to monocular elevation paresis. It may occur in association with pretectal supranuclear lesions either contralateral or ipsilateral to the paretic eye interrupting efferents from the rostral interstitial nucleus of the medial longitudinal fasciculus to the superior rectus and inferior oblique subnuclei. This syndrome has a broad differential diagnosis, encompassing disorders which may cause axial truncal muscle weakness, especially of upper thoracic and paraspinous muscles. Treatment of the underlying condition may be possible, hence investigation is mandatory. They occur sporadically or may be inherited in an autosomal dominant fashion, and are common, occurring in 2% of the population. Drusen are usually asymptomatic but can cause visual eld defects (typically an inferior nasal visual eld loss) or occasionally transient visual obscurations, but not changes in visual acuity; these require investigation for an alternative cause. When there is doubt whether papilloedema or drusen is the cause of a swollen optic nerve head, retinal uorescein angiography is required. Cross References Disc swelling; Papilloedema; Pseudopapilloedema; Visual eld defects 114 Dysarthria D Dynamic Aphasia Dynamic aphasia refers to an aphasia characterized by difculty initiating speech output, ascribed to executive dysfunction. There is a reduction in spontaneous speech, but on formal testing there are no paraphasias, minimal anomia, preserved repetition, and automatic speech. A division into pure and mixed forms has been suggested, with additional phonological, lexical, syntactical, and articulatory impairments in the latter.

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Hepatic failure gastritis znaki purchase discount ditropan line, renal failure gastritis nursing care plan buy generic ditropan pills, respiratory failure (flapIntentional tremor ping tremor or asterixis) gastritis upper back pain purchase ditropan 2.5 mg without prescription. Primary writing/task specific tremor Myoclonic jerks may be a normal phenomenon occurring Dystonic tremor chronic gastritis medicine buy discount ditropan line. It can be present throughout the Generalised Myoclonus range of voluntary movements or when the limbs Progressive myoclonic encephalopathies are maintained in a particular position when it is Hereditary myoclonus known as postural tremor. Nervous System 489 Tics Fibrillation these are repetitive irregular stereotyped movements these are contraction of individual muscle fibres occuror vocalisations which can be imitated. They relaxed and not consciously suppressing them, in can however be perceived over the tongue, where they contrast to most other dyskinesias which are more can be easily seen under the thin mucous membrane. Myokymia these are the most common involuntary movements of the muscles seen as a fine or coarse very rapid rippling Causes of Tics movement of muscle fibres, persisting in the same group of fibres for minutes at a time. Fasciculation this term is applied to an irregular, non-rhythmical Titubation contraction of muscle fascicles. They are best seen in It is the involuntary nodding of the head seen in lesions large muscles such as deltoid or calf muscles. It is a sign of lower motor neuron lesion, Gait and especially a sign of active degeneration of the the gait of the patient may give a clue to the neurological anterior horn cells or irritative lesions of the nerve roots condition. Fasciculation, if not seen at rest, the patient may be asked to walk in a straight line may be brought about by contracting the muscle, for atleast 9 metres and then turn and walk back to the hyperventilation or by cooling the muscle with ethyl starting point. Note is made of the posture of the body while Conditions causing fasciculation walking, the position and movement of the arms, the a. Primary muscular atrophy to maintain a straight course, the ease of turning and. Administration of edrophonium or neostigmine this type of gait is seen in hemiparesis. A reflex is a consistent involuntary adaptive response to the stimulation of a sense organ. The components of Spastic Gait (Bipyramidal Lesion) the reflex arc are: this type of gait is seen in lesions of the upper motor i. The the reflexes to be tested are the superficial reflexes, steps are short with the feet scraping the floor. The deep tendon reflexes are monosynaptic reflexes High Stepping Gait (Foot Drop) and the superficial and visceral reflexes are polysynapthis type of gait is seen in patients with foot drop. The the patient must be appraised of the procedure to patient does not know where his foot is and so, on be adopted in eliciting the various reflexes, as these walking raises his foot high up in the air and brings it reflexes can be easily and correctly elicited only in a down on the ground forcefully (stamping), the heel of completely relaxed patient. This the reflexes may be present, lost or exaggerated abnormal gait is more prominent in the dark or when and thereby give a clue to the underlying neurological the patient walks with his eyes closed. Ataxic Gait (Cerebellar Lesion) Abdominal Reflexes this type of gait is seen in patients with cerebellar lesion. The patient is ataxic and reels in any direction, including Abnormal Responses backwards and walks on a broad base. The patient finds Exaggerated abdominal reflexes may be seen in psychodifficulty in executing tandem walking. Shuffling Gait (Extrapyramidal Lesion) Absent abdominal reflexes may be seen in this type of gait is seen in patients with lesions of the 1. Defects of technique, relaxation, or observation extrapyramidal system, associated with rigidity. A breach of the appropriate reflex arc, due to lesions patient makes a series of small, flat footed shuffles. This such as herpes-zoster, or scar due to surgical operagait is typically seen in parkinsonism, where the patient tions which have damaged the peripheral nerves or has a stooped posture (universal flexion) and walks the muscle itself. The automatic associated upper limb patients with flaccid abdominal muscles, distention movements are absent. Pyramidal system lesions above the upper level of Waddling Gait (Primary Muscle Disease) segmental innervation. The patient walks on a broad base with an neuron disease, cerebral diplegia, infantile hemiplegia exaggerated lumbar lordosis. The examiner fixes the ankle joint Efferent:Tibial nerve phalangeal joint, by holding it and then the outer aspect of accompanied by flexion the sole is stroked with a blunt point (key). The presence of a positive plantar response abdominal muscle contraction and retained upper can then be assessed by feeling for the contraction of abdominal reflexes, whereas there is absence of lower tensor fascia lata and adductors of the thigh. Pseudo-Babinski Sign False Babinski sign may sometimes occur in the absence the Plantar Reflex of pyramidal tract lesion. As a response in plantar hyperesthesia this response is seen with lesions of the corticospinal c. In athetosis or chorea, where the big toe may extend of the great toe, along with extension and fanning out as a response to dystonic posturing. If the short flexors of the toes are paralysed (due to In addition, especially if the response is marked, lower motor neuron lesion), there may be an there is dorsiflexion at the ankle, with flexion at the inversion of the plantar reflex. Pressure on the base of Pressure on the base of the aspect of the foot when the lesion becomes dense (due the great toe while great toe while eliciting the to increase in the reflexogenic area). Infancy (up to 1 year of age) With repeated stimulation of the sole of the foot, the 2. Following electroconvulsive therapy Plantar response is said to be equivocal in following 7. There is only extension of great toe or extension of whereas in the phase of active respiration the great toe with flexion of small toes. There is no response to plantar stimulation, particularly if there is paralysis of dorsiflexors. Chaddock reflex: A light stroke is applied below the patient lies down in a partially propped up position. Proper positioning of the limbs for elicitation of the these reflexes show a positive Babinski response deep tendon reflexes is important. The deep tendon reflexes are best elicited using a They may be useful in eliciting the Babinski response long and flexible knee hammer and the examiner when the patients are uncooperative or in patients whose allowing the weight of the hammer to decide the soles are extremely sensitive (Fig. Grade 3 Exaggerated the examiner pronates his hand and links his flexed Grade 4 Clonus. Lesion of the sensory nerve (polyneuritis) middle finger is flicked downwards between the examb. Lesion of the anterior horn cell (poliomyelitis) of the other fingers flex and the thumb flexes and d. Exaggerated Tendon Reflexes Reflexes may be brisk if the patient is agitated, frightened, or anxious.