William J. Fulkerson, MD

  • Professor of Medicine

https://medicine.duke.edu/faculty/william-j-fulkerson-md

The Q-sort consists of set of cards allergy symptoms gagging purchase 250mcg seroflo, each of which provides a short state ment about character or personality allergy symptoms back pain generic 250 mcg seroflo overnight delivery, which may be positive allergy forecast netherlands purchase generic seroflo line, neutral or negative allergy zithromax symptoms seroflo 250 mcg line. Among other uses, the Q-sort has been employed in studies of the efficacy of client-centered therapy. If two things are qualitatively different, it implies that arithmetic comparisons between them are not appropriate, as they are of a different nature, like chalk and cheese. Dictionary of Psychology & Allied Sciences 339 Quantitative variable: An object to observation which varies in manner or disagree in such a way it may be measured. Quantity: In this Project for a Scientific psychology which has written in 1895 but only published posthumously in 1950. Q was conceived as being attached to neurons and of being capable of passing from one neurone to another. The classical theory postulated the existence of quanta of psychic energy which are generated in the Id, which are capable of being discharged in action and of being bound (attached) to those mental structures which constitute the Ego. Quota sampling: A system of obtaining a sample for a study which involves identifying a set of represen tative sub-groups within the population, and taking a number of subjects from each of these sub groups. The size of each sub-group in the sample depends on its proportional size in the original population. For instance, in a study of student attitudes to their Technical College, the sample would be picked to represent the same proportions of different types of students as were found in the college as a whole-if 10% of the students were on same day-release courses, then 10% of the sample would be drawn from the day-release students. Because these tests usually measure something valued by European culture, and because their objectivity has been overestimated, findings of lower scores, for example on intelligence tests, of ethnic minority groups have been used as the basis for claims of racial superiority. These claims have then led to a rather more careful inspection of the evidence and it is now recognized that neither race nor intelligence can be defined or measured with enough accuracy to justify claims about the rela tionships between them. Racism: Discrimination, prejudice or unfair practice towards someone which occurs purely on the basis of their ethnic group or skin colour. Random: A statistical term that means occurring by chance or without attention to selection or planning. A random sample of a given population consists of a group of subjects selected in such a manner that each member of the population has an equal probability of being selected for the sample. Random sample: A group of subjects selected in such a way that each member of the population from which the sample is derived has an equal or known change (probability) of being chosen for the sample. Range: A statistical measure of the variability of a set of values defined as the difference between the largest value and the smallest value. He split with Freud on the significance of the birth trauma, which he used as a basis of brief psychotherapy. Each phase usually lasts about 20 minutes, before the subject passes on the one of the deeper, quiescent levels of sleep. Rapport: Conscious feeling of harmonious accord, sympathy, and mutual responsiveness between two or more persons. Rapport contributes to an effective therapeutic process in both group and individual settings. It is also known as nitrogen narcosis because of its association with excessive blood nitrogen levels. Sensory deprivation may 342 Dictionary of Psychology & Allied Sciences also contribute to this acute, self-limited mental disorder. The test consists of a series of grids or matrices of 8 patterns from which the 9th can be deduced logically, and a set of patterns of which one is the missing 9th pattern and therefore the correct answer. The special feature of the test is that it is entirely non-verbal and it is even possible to administer it to someone with whom the tester shares no language at all. Despite the attempt of Raven to make the test independent of culture, it still reflects some cultural assumptions and experience. In many cultures manipulation of and or interest in abstract forms of this kind are not regarded as particularly desirable human activities. Dictionary of Psychology & Allied Sciences 343 Reactance: the tendency of people to be made uncom fortable by any restriction of their freedom of choice. Reaction: this is used rather loosely for any changes in the psychological state which is brought about by external events which do not damage the brain. Reaction formation: An unconscious defense mecha nism in which a person develops a socialized attitude or interest that is the direct antithesis of some infantile wish or impulse that he harbours either consciously or unconsciously. One of the earliest and most unstable defense mechanisms, it is closely related to repression; both are defenses against impulses or urges that are unacceptable to the ego. Reaction time: A measure of how quickly a person can produce an accurate response to a stimulu. Reac tion time has been used by psychological resear chers in a wide range of investigations, including ageing, decision-making, drug effects and vigilance. It provides a rapid and reliable measure, which is highly sensitive to disturbance by additional or extraneous factors. Reactive depression: this term is used by many English speaking psychiatrists in a rather ill-defined way. It can mean a state of unhappiness which has occurred as a response to some psychological trauma or, in other words, excessive normal unha ppiness. It can also mean a depressive illness which has been provoked by a psychological upset or in which the symptoms fluctuate in response to environmental changes. Reactive schizophrenia: Unofficial term for schizo phrenia attributed primarily to predisposing or precipitating environmental factors. According to classical theory, the infant is totally maladapted and obeys the Pleasure-principle without reference to external reality. Reality principle: According to Freud, mental activity is governed by two principles; the pleasure prin ciple and the Reality principle, the former leading to relief of instinctual tension by hallucinatory wish-fulfillment the latter to instinctual gratification by accommodation to the facts of and the objects existing within the external world. Reality testing: Fundamental ego function that consists of tentative actions that test and objectively eva luate the nature and the limits of the environment. It includes the ability to differentiate between the external world and the internal world and to accu rately judge the relation between the self and the environment. Falsification of reality, as with massive denial or projection, indicates a severe disturbance of ego functioning and/or the perce ptual and memory processes upon which it is partly based. Dictionary of Psychology & Allied Sciences 345 Recall: the process of bringing a memory into cons ciousness. Recall is often used to refer to the recoll ection of facts, events and feelings that occurred in the immediate past. Recency effect: A learning effect in which the items which occurred most recently in a sequence are more likely to be recalled than those which occurred earlier on. Receptor: the term is usually used to mean sense receptor, a specialized cell or group of cells which picks up sensory information, either from within (see proprioceptors) or outside of the body, and converts it into electrical impulses for transmission to the central nervous system. So, for example, the light-sensitive rod and cone cells of the eye are receptors, as are the hair cells in a the organ of Corti in the ear, and the pressure-sensitive cells in the skin. Receptor site: A location on the dendrite of a neurone, opposite a synaptic knob, which is sensitive to and readily absorbs a specific chemical. The appro priate chemical is released into the synaptic cleft from vesicles on the synaptic knob of the opposing neurone, and functions as neurotransmitter, render ing the receiving neurone more or less ready to fire.

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Volume 12, A 108 Advances in Drug Testing and Drug Delivery Systems, 79 3D Reconstruction: Techniques, Analysis and New Advances in Energy Research. Volume 24, 116 5G Mobile: From Research and Innovations to Deployment Advances in Energy Research. Volume 13, 118 A Handbook on Estrogen Receptors in the Brain, 45 Advances in Engineering Research. Volume 14, 118 A New Approach to Stuttering: Diagnosis and Therapy, 227 Advances in Engineering Research. Volume 15, 119 A Note on Inheritance and Generalizability Properties in Advances in Engineering Research. Volume 53, 121 Volume 1: Organization and Management, 34 Advances in Environmental Research. Volume 55, 122 Volume 2: Basics of Blood Bank Practices (Process Control), Advances in Marine Biology. Volume 25, 143 Volume 3: Good Clinical Transfusion Practices, 35 Advances in Materials Science Research. Volume 26, 143 Accessing Justice through Mental Health Law Reform in the Advances in Materials Science Research. 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Alternatives to punishment: Solving Behavior problems with nonaversive strategies. They are about difficult events people may experience, especially the emotional aspects of such events. The books actively address the problems of understanding that people with learning and communication difficulties experience. The stories are told through colour pictures, helping readers to cope with events such as going to the doctor, bereavement, sexual abuse and depression. The stylised drawings include mime and body language to communicate simple, explicit messages to the reader. Genetics (Gk genno, to give birth) have come to psychiatry to stay, (Emery, 1991; Murray & McGuffin, 1993; Iles, 2009) and with them have arrived a plethora of ethical and social issues, not least of which is the involvement of the commercial sector. Nearly all genetically-influenced behaviours, be they normal or abnormal, are likely to reflect the additive effects of more than one gene (at different loci). Also, psychiatric disorders have developed improved reliability as distinct from proven validity over the years, i. The reasons why a disorder is familial include genetic, early and current shared environments. Geneticists divide environmental factors into unique (to siblings in the same family) and common/shared (by siblings in the same family). Point mutations are created by changes in a single base pair (the simplest mutation) or by the deletion or insertion of one gene; if the coding region is affected then a codon may be made that leads to a missense or nonsense mutation with the production of the wrong amino acid or (because of changed sequence to a stop codon) or an incomplete protein. Pseudogene Mutated gene duplication incapable of translation into functional proteins May misalign with neighbouring normal gene during meiosis Any crossover may mutate the normal gene E. Apparently, those proteins 861 containing more than 50 glutamine molecules form tight intranuclear balls that are lethal to the cell. It includes the ortholog (keeps same function) and the paralog (genes related by duplication within a genome; this evolves a novel function, even if it is only a slightly different one). Despite being from the one gene, exons may be spliced together in different ways so that different proteins may be manufactured in different tissues. This means that organisms did not need to add many new genes over evolutionary time in order to become more complex. They translate extracellular signals into alterations in intracellular neuronal function by regulating the expression of other genes, the latter being referred to as late-response or target genes. These are named from 1-22 in terms of decreasing length; there is also a pair of sex chromosomes, X and Y, or X and X. A father cannot transmit an X-linked trait, be it dominant or recessive, to his son. A euploid cell contains an exact multiplication of the monoploid number of chromosomes, the normal euploid number in humans being 46, i. Humans, being diploid, normally have 2 copies of each 864 Introns were once seen as merely evolutionary vestiges. However, they can influence the pattern of gene slicing and an intron variant may point toward a functionally important variation in another part of the gene. Additionally, hormone levels and other extracellular factors exert influences on transcription. Transcription factors are required for the normal differentiation of cortical nerve cells. Mitosis is artificially divided into 872 interphase, prophase, metaphase, anaphase and telophase. It is also called reduction division, because the number of chromosomes in the cells produced by meiosis is halved. Put another way, each gamete receives either of a pair of homologous (matching) chromosomes. Four haploid gametes are present at the end of meiosis: in the case of the male germline these are retained as sperm, whereas in the female germline only one is retained as an ovum, the other three forming polar bodies. The process of meiosis consists of 2 steps, each with a prophase, metaphase, anaphase and telophase. Crossing over, the exchange of genetic material between chromatids of maternal and paternal homologous chromosomes, may occur when these chromosomes are paired during prophase of the first meiotic division. Half of all spontaneously aborted foetuses in the first trimester have major chromosomal abnormalities. A biological marker is a biological characteristic or abnormality that may be associated with an abnormal gene or a gene close to (linked) to that gene. Unfortunately, some markers are state rather than trait markers, the latter being more informative. He described the phenomenon of independent assortment: the pattern of inheritance for one trait was unaffected by the transmission of another trait. For example, Mr A got a copy of chromosome 12 from his mother (another the other copy from his father) which is a mix of her 2 copies of that chromosome, one of which came from her mother (the other from her father), and so on back through the generations. If the recombination fragment, a measure of the recombination event, is close to zero, linkage (inheritance of 2 or more markers as a single unit because of their close proximity on the chromosome and not because of chance) is likely. In other words, the lod score is the log of the odds on linkage in genetic research: the logarithm of the odds ratio. The odds ratio equals the odds of the observed pattern of co-segregation between marker and disorder occurring if the marker and disorder are linked divided by the odds of the same co-segregation occurring if the marker and disorder are not linked. Pacitaxel, used to treat cancer, bind to microtubules and prevents movement or organelles. This action prevents formation of mitotic spindles and leads to death of the cell. The pseudoautosomal region of the sex chromosomes is a segment of sequence homology between the X and Y chromosomes in which meiotic cross-over (recombination) can occur. Depending on its exact location, a gene situated within this region could be inherited either in an autosomal or in a sex-linked manner. Normally, one X chromosome exists in an inactive, packaged state, formed during the late blastocyst stage: heterochromatic Barr body. They can be caused by the environment during life and then be passed on to progeny. Such processes can change phenotypes and might explain why major psychiatric disorders do not follow the Laws on Mendel and they may explain how environmental factors translate into biology.

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What may be more important is the reason for the loss it may be unrelated if it occurs through natural causes and it may be more related to parental discord and intentional separation of parent from child allergy zithromax symptoms seroflo 250 mcg with visa. Deprivation of love may be an important psychological risk factor in the background of depressive disorders quick allergy treatment purchase generic seroflo line. Bereavement in the elderly is a life event with significant consequences for personal health allergy shots and eczema buy 250 mcg seroflo amex. Local resources allergy yeast symptoms rash discount seroflo 250mcg amex, official and voluntary, are employed in crisis intervention to avert disaster, such as suicide. An interesting problem is the case of the demented spouse who functions reasonably well before the death of the supervising partner, only to need institutional care immediately thereafter. It has been recognised for many years now that the mortality rate rises steeply among the bereaved during the first 6-12 months after bereavement. Rahe, in the 1960s, found that the death of a spouse was regarded as possibly the most stressful of life events. Bereavement may be associated with increased adrenocortical activity and increased serum prolactin and growth hormone levels. Grief stages (numbness, pining, disorganisation/despair, and reorganisation) are not rigid and can pass back and forth. Caplan urged that professional help be given early in social crisis, believing that the best work can be done in the initial 4-6 weeks, it being then that the patient is most open to influence. In the 1970s, Mechanic divided people experiencing stress into Copers and Non-Copers. Important determinants of this are previous experiences of stress and the circumstances prevailing at the time, presently available supports, affective state, and the symbolic significance of the event and its immediate antecedents for the individual. During the early 1940s, Adler examined 46 victims of the Coconut Grove disaster who were treated in a Boston hospital. There is little scientific evidence 1564 to support a contention that the Samaritans have any real effect in reducing the suicide figures, although they do provide a valuable service for the distressed and lonely. Also, there is evidence that contacting people by telephone one month after discharge from an emergency department for deliberate self-poisoning may help to decrease the number of repeat attempts over one year. The symptoms of grief include preoccupation with the lost object (limb, function, person), physical distress, inappropriate behavior, hostility and denial. Amputation or loss of a body part can be particularly problematic in those who avoid facing up to the loss, are obsessed with it, or who have unresolved sexual problems. Parkes (1978) examined the fears of the dying and believed that while they might be viewed as realistic fears the physician had a role to play. The chief fears found were removal from relatives, familiar environment, and occupation, plight of dependants, losing control, crying, or not dying well, being a burden, lack of self-sufficiency because of weakness, and incontinence, confusion, or mutilation. What constitutes a good death varies with the individual, (Saunders ea, 2003) religion and secularism. Shelley (1986) advocated the use of routine assessment of terminally ill patients by a psychiatrist and included social workers and a clerical dimension in the team. Patients with good premorbid personalities who are able to express their feelings are able to cope better. Those with a past history of unresolved painful loss are sensitised to their own potential loss. Most cases feared the process of dying more than death itself; the former process was associated with fears of pain, loss of body function, lack of dignity, as well as being a burden on their families. Denial (common) could inhibit emotional resolution or 1564 1850 60 90 90, jo@samaritans. This may become apparent, for example, when there is a recurrence of a fatal disorder. Identification with patients and idealisation, especially of the doctor, were common. Female doctors and those who cared for patients for prolonged periods of time may experience particularly strong emotional reactions to the death of patients, and junior doctors need support from their seniors on such occassions. Brugha (1993) divided decreased mood in the terminally ill into appropriate and transient feelings of loss and grief, depressive adjustment reaction, and depressive illness, although the distinction between the latter two can be difficult to make in practice. Depression may be under treated in this group for a number of reasons, such as viewing it as appropriate to the circumstances or considering treatment so close to death as being inappropriate. The same care must be taken when explaining antidepressant drugs (and in choosing which one to use) to the dying as is required at other times. The stronger is the religious belief among relatives or friends of a dying person the more quickly and completely is resolution of grieving in survivors. Children often know that they are dying but are rarely asked how they feel about it. Survivors need help, support, information, explanation and, if requested, to see the body. The reasons for referral, in order of frequency, are behaviour problems, depression, anxiety, communication difficulties, possible psychogenic complaints, anticipation of problems. The psychiatric diagnoses most frequently made are depression, anxiety, and various acute and chronic organic brain syndromes. The extended family as distinct from the smaller nuclear family and the wake with their opportunities for support and for successful grieving are almost things of the past. The modern term (neurosis) embodies an absence of an organic brain disorder, retention of insight (in touch with external reality), and a personality (whilst often somewhat disordered) that is not grossly abnormal. All neurotic disorders share precipitating, perpetuating and predisposing factors. Jean Fernel of Paris claimed that humans could change into animals by the action of demons (lycanthropy). Smollius, in 1610, used the term hypochondriasis because of the belief that certain mental states were due to subchrondral organ (liver, spleen) dysfunction. Thomas Willis, in 1667, stated that the origin of hysteria was not in the womb, as was the then current theory, but rather in the brain. Jeremy Bentham, philosopher and lawyer of the early nineteenth century, believed that we express those motives and desires that we find to be unacceptable to us in a disguised or symbolic way. It has been suggested that neurasthenia arose in a setting of increased preoccupation with commerce and material success and major changes in the role of women. In a large study of diagnoses in a population of 300, 000 people in general practice carried out in the early 1970s in Britain the consultation rate for all neurotic states was 75. The neuroses were found to be very common among the inpatients and outpatients of hospital specialities other than psychiatry. Two-thirds of psychiatric cases seen in general practices were diagnosable as neurotic during the 1960s. Neuroses commonly presented with individual symptoms, the undifferentiated syndrome being a form commonly seen in general practice, psychiatrists more usually seeing specific syndromes, although diagnostic instability over time is very common. The most common symptoms were fatigue (27%), sleep problems (25%), irritability (22%), and worry (20%). It should be noted, however, that, during a given year, 3-7% of children fulfil criteria for overanxious disorder of childhood. Behavioural: Maladaptive activity, exaggerated affect, inability to change, preservation of insight; aware behaviour is irrational and inappropriate but feels unable to stop it; learned phenomenon. However, neurotic (emotionally reactive temperament) behaviour often persists without any obvious reinforcement. The early learning theories of Pavlov and Skinner cannot account fully for human learning. Since then there has been increased attention to cognitions intermediate between stimulus and response. It has been suggested that his phallic phase should be renamed the infantile genital stage, the adult genital stage not commencing until puberty.