Joseph Stavas, MD

  • Associate Professor of Radiology
  • University of North Carolina School of Medicine
  • Chapel Hill, North Carolina

Preparis: A Guide to Successful Tabletop Exer Modern Behavioral Intervention Teams should have a variety of tools symptoms of depression cheapest generic quetiapine uk, cises treatment 3 nail fungus quetiapine 200 mg line. Retrieved on July 17 treatment 1st line buy quetiapine 50 mg low price, evaluate their tools and resources to determine their current state of 2015 from Tabletop exercises have long been used by law enforce ment and emergency management teams to prepare for what they Reuters (June 20 medicine 2 quetiapine 200 mg without a prescription, 2015). Inserting fctional characters to a scenario may be necessary to allow the conversation to fow around Sokolow, B. Roof, 21, who authorities say spent an hour in Bible study with pa rishioners at the nearly 200-year-old Emanuel African Methodist Episcopal Church before opening fre on Wednesday night, appeared via video feed before a magistrate judge who on Friday ordered him Dylann Roof Photo: Reuters held without bond. Friends of the white gunman who shot and killed nine black He has been charged with nine counts of murder and a weapons ofense. African-American history followed a wave of protests across the United States in recent months over police killings of unarmed black men, fo the Washington Post reported 22-year-old Christon Scriven, a cusing attention on racial bias in the criminal justice system and renew black neighbor of gunman Dylann Roof, said that during a recent ing a civil rights movement under the banner of Black Lives Matter. In several of these, he is seen to be wearing a jacket stitched with the flag of the white supremacist state of Rhodesia. You are almost surely In a modern history class it is always emphasized that, when talking about going to feel very sorry for that dog. But then say you were to witness a dog bad things Whites have done in history, they were White. You will most likely not feel the same pity you felt for the dog about the numerous, almost countless wonderful things Whites have done, it every White person has a small amount of racial awareness, simply beause for the man. But it is a superfcial anything important done by a black person in history, it is always pointed out awareness. Growing up, in school, the White and black kids would make this same analogy applies to black and White relations. For example when we learn about how George racial jokes toward each other, but all they were were jokes. They are held Washington carver was the frst nigger smart enough to open a peanut. This is why they are able to get away with blacks were the real racists and other elementary thoughts like this, but things like obnoxious behavior in public. The reason for this is that White culture Modern history classes instill a subconscious White superiority complex in is world culture. I dont mean that our culture is made up of other cultures, the event that truly awakened me was the Trayvon Martin case. This White superiority complex I mean that our culture has been adopted by everyone in the world. I read that comes from learning of how we dominated other peoples is also part makes us feel as though our culture isnt special or unique. Say for example the Wikipedia article and right away I was unable to understand what the of the problem I have just mentioned. But of course I dont deny that we are that every business man in the world wore a kimono, that every skyscraper big deal was. This would probably make a Japa Google, and I have never been the same since that day. The frst website I I wish with a passion that niggers were treated terribly throughout history nese man feel as though he had no unique traditional culture. There were pages upon by Whites, that every White person had an ancestor who owned slaves, pages of these brutal black on White murders. Because I have noticed a great disdain for race mixing White women within the moment I realized that something was very wrong. How could the news be if it was all it true, it would make it so much easier for me to accept our White nationalists community, bordering on insanity it. These women are blowing up the Trayvon Martin case while hundreds of these black on White current situation. I have tried endlessly to think of Jews From this point I researched deeper and found out what was happening in reasons we deserve this, and I have only came back more irritated because Unlike many White naitonalists, I am of the opinion that the majority of Europe. I saw that the same things were happening in England and France, there are no reasons. In my opinion the issues with jews and in all the other Western European countries. As an American we are taught to accept living in the melting pot, Only a fourth to a third of people in the South owned even one slave. The prob and black and other minorities have just as much right to be here as we do, every White person is treated as if they had a slave owning ancestor. This lem is that Jews look White, and in many cases are White, yet they see them since we are all immigrants. But Europe is the homeland of White people, applies to in the states where slavery never existed, as well as people whose selves as minorities. Just like niggers, most jews are always thinking about and in many ways the situation is even worse there. If we could about the Jewish problem and other issues facing our race, and I can say slaves narratives from my state. One somehow turn every jew blue for 24 hours, I think there would be a mass today that I am completely racially aware. Blacks narratives the slaves told of how their masters didnt even allowing whipping I think it is is ftting to start of with the group I have the most real life experi on his plantation. Not only did it protect us from having to interact cial awareness is, its viewing everything that happens through a racial lense. Integration has done nothing but reason they get ofended so easily, and think that some thing are intended bring Whites down to level of brute animals. The best example of this is to be racist towards them, even when a White person wouldnt be thinking obviously our school system. Now White parents are forced to move to the suburbs to send their children Black people are racially aware almost from birth, but White people on to good schools. To me it represents 5458 the Journal of Campus Behavioral inTervenTion nothing but scared White people running. Running because they are too In a modern history class it is always emphasized that, when talking about weak, scared, and brainwashed to fght. Why should we have to fee the bad things Whites have done in history, they were White. Why are the suburbs secure about the numerous, almost countless wonderful things Whites have done, it in the frst place The pathetic part is that these is never pointed out that these people were White. Yet when we learn about White people dont even admit to themselves why they are moving. They tell anything important done by a black person in history, it is always pointed out themselves it is for better schools or simply to live in a nicer neighborhood. For example when we learn about how George But it is honestly just a way to escape niggers and other minorities. Many White people feel as though White children who, because of school zoning laws, are forced to go to a they dont have a unique culture. I dont mean that our culture is made up of other cultures, be able to go one day without being picked on for being White, or called I mean that our culture has been adopted by everyone in the world. Who is fghting for these White makes us feel as though our culture isnt special or unique. No one, that every business man in the world wore a kimono, that every skyscraper but someone has to . This would probably make a Japa Here I would also like to touch on the idea of a Norhtwest Front. Why should I for example, give up the beauty and history of my state to go to the Norhthwest To me the whole idea just par I have noticed a great disdain for race mixing White women within the ralells the concept of White people running to the suburbs. These women are is pathetic and just another way to run from the problem without facing it. Some people feel as though the South is beyond saving, that we have too Jews many blacks here. The South had a higher ra Unlike many White naitonalists, I am of the opinion that the majority of tio of blacks when we were holding them as slaves.

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Since prostate cancers often have areas with different grades medicine man aurora order quetiapine 300 mg on-line, a grade is assigned to the 2 areas that make up most of the cancer treatment quincke edema buy discount quetiapine 200 mg online. These 2 grades are added to yield the Gleason score (also called the Gleason sum) symptoms dehydration discount 50 mg quetiapine with amex. For example chapter 9 medications that affect coagulation quetiapine 200 mg with amex, if the Gleason score is written as 3+4=7, it means most of the tumor is grade 3 and less is grade 4, and they are added for a Gleason score of 7. Although most often the Gleason score is based on the 2 areas that make up most of the cancer, there are some exceptions when a biopsy sample has either a lot of high grade cancer or there are 3 grades including high-grade cancer. In these cases, the way the Gleason score is determined is modified to reflect the aggressive (fast-growing) nature of the cancer. In theory, the Gleason score can be between 2 and 10, but scores below 6 are rarely used. Grade Groups In recent years, doctors have come to realize that the Gleason score might not always be the best way to describe the grade of the cancer, for a couple of reasons: q Prostate cancer outcomes can be divided into more than just the 3 groups mentioned above. For example, men with a Gleason score 3+4=7 cancer tend to do better than those with a 4+3=7 cancer. And men with a Gleason score 8 cancer tend to do better than those with a Gleason score of 9 or 10. For example, a man with a Gleason score 6 cancer might assume that his cancer is in the middle of the range of grades (which in theory go from 2 to 10), even though grade 6 cancers are actually the lowest grade seen in practice. This assumption might lead a man to think his cancer is more likely to grow and spread quickly than it really is, which might affect his decisions about treatment. Because of this, doctors have developed Grade Groups, ranging from 1 (most likely to grow and spread slowly) to 5 (most likely to grow and spread quickly): q Grade Group 1 = Gleason 6 (or less) q Grade Group 2 = Gleason 3+4=7 q Grade Group 3 = Gleason 4+3=7 q Grade Group 4 = Gleason 8 q Grade Group 5 = Gleason 9-10 the Grade Groups will likely replace the Gleason score over time, but currently you might see either one (or both) on a biopsy pathology report. Other information in a pathology report 21 American Cancer Society cancer. For more information about how prostate biopsy results are reported, see the Prostate 6 Pathology section of our website. Genetic testing for some men with prostate cancer Some doctors now recommend that some men with prostate cancer be tested to look 7 for certain inherited gene changes. Talk to your doctor about the possible pros, cons, and limitations of such testing. Imaging tests for prostate cancer Imaging tests use x-rays, magnetic fields, sound waves, or radioactive substances to create pictures of the inside of your body. One or more imaging tests might be used: q To look for cancer in the prostate q To help the doctor see the prostate during certain procedures (such as a prostate biopsy or certain types of prostate cancer treatment) q To look for spread of prostate cancer to other parts of the body Which tests you might need will depend on the situation. If you are found to have prostate cancer, you might need imaging tests of other parts of your body to look for possible cancer spread. The probe picks up the echoes, and a computer turns them into a black and white 23 American Cancer Society cancer. You will feel some pressure when the probe is inserted, but it is usually not painful. A contrast material called gadolinium may be injected into a vein before the scan to better see details. It can also help show if the cancer has grown outside the prostate or spread to other parts of the body. This can help ensure the doctor gets biopsy samples from any suspicious areas seen on the images. Bone scan If prostate cancer spreads to distant parts of the body, it often goes to the bones first. For this test, you are injected with a small amount of low-level radioactive material, which settles in damaged areas of bone throughout the body. A special camera detects the radioactivity and creates a picture of your skeleton. However, newer tracers, such as fluciclovine F18, sodium fluoride F18, and choline C11, have been found to be better at detecting prostate cancer cells. Still, it can sometimes help tell if prostate cancer has spread into nearby lymph nodes. Lymph node biopsy In a lymph node biopsy, also known as lymph node dissection or lymphadenectomy, 15 one or more lymph nodes are removed to see if they have cancer cells. This isnt done very often for prostate cancer, but it might be used to find out if the cancer has spread from the prostate to nearby lymph nodes. Lymph node biopsy as a separate procedure A lymph node biopsy is rarely done as a separate procedure. The skin is numbed with local anesthesia before the needle is inserted to take a small tissue sample. A contemporary prostate cancer grading system: A validated alternative to the Gleason score. Accessed at 28 American Cancer Society cancer. Last Revised: December 10, 2020 Prostate Cancer Stages and Other Ways to Assess Risk After a man is diagnosed with prostate cancer, doctors will try to figure out if it has spread, and if so, how far. The pathologic this likely to be more accurate than the clinical T, as it is done after all of your prostate has been examined in the lab. Numbers or letters after T, N, and M provide more details about each of these factors. The cancer has not spread to nearby lymph or less) nodes [N0] or elsewhere in the body [M0]. The cancer (Gleason score 6 has not spread to nearby lymph nodes [N0] or or less) elsewhere in the body [M0]. The cancer has not spread to nearby lymph nodes [N0] or elsewhere in the body [M0]. It is in more than half of one side of the prostate [cT2b] or it is in Grade Group 1 both sides of the prostate [cT2c]. The cancer has not (Gleason score 6 spread to nearby lymph nodes [N0] or elsewhere in the or less) body [M0]. It might (or might not) be felt by digital rectal exam or Grade Group 2 seen with imaging such as transrectal ultrasound [T1 or (Gleason score T2]. It might (or might not) be felt by digital rectal exam or Grade Group 3 or 4 seen with imaging such as transrectal ultrasound [T1 or (Gleason score T2]. The cancer has not spread to nearby lymph nodes or less) [N0] or elsewhere in the body [M0]. Any T, N0, M0 the cancer might or might not be growing outside the 32 American Cancer Society cancer. The cancer might or might not be growing into tissues Any T, any N, M1 near the prostate [any T] and might or might not have spread to nearby lymph nodes [any N]. If you have any questions about your stage, please ask someone on your cancer care team to explain it to you in a way you understand. Genomic and proteomic tests Another way to get an idea of how quickly a prostate cancer might grow or spread is with lab tests that look at which genes (or proteins) are active inside the prostate cancer cells. Accessed at 34 American Cancer Society cancer. Last Revised: August 1, 2019 Survival Rates for Prostate Cancer Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time (usually 5 years) after they were diagnosed. Thee rates cant tell you how long you will live, but they may help give you a better understanding of how likely it is that your treatment will be successful. Talk with your doctor about how these numbers may apply to you, as he or she is familiar with your situation. A relative survival rate compares people with the same type and stage of cancer to people in the overall population. For example, if the 5-year relative survival rate for a specific stage of prostate cancer is 90%, it means that men who have that cancer are, on average, about 90% as likely as men who dont have that cancer to live for at least 5 years after being diagnosed. Prostate cancer 5-year relative survival rates these numbers are based on men diagnosed with prostate cancer between 2009 and 2015. They do not apply later on if the cancer grows, spreads, or comes back after treatment. Treatments improve over time, and these numbers are based on men who were diagnosed and treated at least five years earlier. Here are some questions you might want to ask: When youre told you have prostate cancer q What are the chances that the cancer has spread beyond my prostate

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Until more is known symptoms xxy effective 300mg quetiapine, the combination of cisapride and dolasetron should probably be avoided symptoms gestational diabetes order quetiapine master card. Weimaraners symptoms tuberculosis purchase quetiapine visa, Rottweilers medicine 6 year program quetiapine 200 mg fast delivery, German shepherds, and border collies are at higher risk. Dogs with food-responsive enteropathy tend to be younger, (average age 3 years) and can be as young as 8 months at disease onset. Additional biopsies of the liver, pancreas, and lymph nodes can be based on clinical presentation and gross appearance. However, the additional cost, time of hospitalization, and potential complications of surgical biopsies can be a barrier to many owners. In some situations, however, a biopsy may not be possible, such as a client with financial constraints or a patient with contraindications for anesthesia. Novel protein (elimination) diets are designed to avoid exposure to proteins to which the gut mucosal immune system may have been previously sensitized. Most commercial elimination diets contain a novel protein source, are free of milk, corn, and wheat, and are highly digestible with moderate soluble fiber. I choose hydrolyzed diets first because so many of the novel protein sources are now available in commercial over the counter pet foods. Immunosuppressive drug therapy In dogs and cats with a biopsy diagnosis of moderate to severe inflammatory gastrointestinal disease, with clinical signs that are not responsive to dietary change, the standard of care remains immunosuppressive drugs. Prednisone or prednisolone: Prednisone is a pro-drug and is converted into active prednisolone after administration. Therefore, prednisolone is optimal for glucocorticoid administration in cats, especially those without a prompt response to prednisone. Budesonide undergoes extensive hepatic clearance in humans, which leads to lower systemic drug concentrations and associated side effects. The drug is supplied in 3 mg enteric coated gel caps, and must be reformulated to provide the recommended empirical dosage of 0. Azathioprine is both anti-inflammatory and immunosuppressive, and may be used as an add-on agent for severe cases of chronic enteropathies dogs. Also generates protective renal prostaglandins and is important for healing of gastric ulcers once they occur C. Better efficacy than either meloxicam or buprenorphine for post operative pain control in cats (Kamata 2012, Staffieri 2013). Less effective than meloxicam for post-laparoscopic pain in one study in dogs (Bendinelli 2019) B. Prostaglandins are critical for renal perfusion in patients with low renal blood flow a) Prostaglandins increase renal arterial blood flow in response to a drop in renal perfusion b) Prostaglandins also stimulate renin release 2. Carprofen leads to mild subclinical decreases in platelet aggregation, but neither carprofen nor meloxicam prolong buccal mucosal bleeding times in healthy dogs C. Deracoxib, firocoxib, and robenacoxib do not affect buccal mucosal bleeding time in dogs 2. In humans, both cholestasis and fulminant hepatic failure have been reported with coxibs. Those with a fixed mindset hold a belief that basic qualities, such as intelligence or musical ability, are fixed and cannot be changed. People with a fixed mindset frequently believe that talent leads to success, not effort. Those with a growth mindset believe that the most basic qualities can be cultivated with hard work and 1 dedication; brains and talent simply provide a foundation. Resilience has been described as a state of being that promotes wellness and decreases the 2 impact of physical and psychological stress. One theory of resiliency describes five key principles that resilient individuals embrace: managing health, problem-solving, increasing strengths (self-esteem, self-confidence, and self-concept), developing positive response 2 choices, and learning good lessons from difficult situations. Research has demonstrated that 3 individuals that possess higher levels of resiliency recovered faster from threats. Self compassion and mindfulness have been found to be positively associated with resiliency levels 4 and protective against burnout. It is in the areas of increasing strengths, developing positive response choices, learning good lessons from difficult situations, and self-compassion that mindset factors into the development of resilience. The link between mindset and resilience is apparent when one considers the impact of the mindset one holds. A growth mindset, believing that one can grow and change, reduces the fear trying a new thing, of failing, or of 5 making a mistake. A growth mindset allows you to be resilient in the face of an unexpected outcome because you do not feel threatened and it does not elicit doubt in your identity. In the case of a fixed mindset, one doesnt believe that another can grow and change a given personal characteristic. Consider how you would treat someone you dont believe has the capacity to change You may determine you dislike who they are, versus disliking their performance or behaviour. It takes some purposeful intention to adopt a growth mindset, however, the benefits of doing so are multifaceted and abundant. One of the best parts about deciding to incorporate growth mindset into your life is that all that is needed to do so is an awareness of the power of the mindset one holds. Interventions show that when students are taught about fixed and growth mindsets, that the information they are given is all that is needed for them to make positive 2,5 changes and go forward using a growth mindset. Choosing to adopt a growth mindset will not only improve your own resilience and capacity for growth, it will strengthen your relationships with those around you and facilitate team performance. Mindsets that promote resilience: When students believe that personal characteristics can be developed. What Factors Promote Resilience and Protect Against Burnout in First-Year Pediatric and Medicine-Pediatric Residents Finances are a key part of the decision-making process for many owners, so it should be discussed from the beginning. The unwillingness or inability to pay for a private school for a child does not mean that the child is not cared for o Ex. In some contexts, it is also valuable info to share with the clientele, and general public (family, friends). Money often adds another stressful aspect to the situation, they are not lashing out at you because youre a bad person, they are probably feeling a range of emotions and havent had time to process them. A better relationship with clients = better communication, which may in turn decrease the amount of complaints and negative feedback received. Equally important, the life stages described in the guidelines also represent a useful framework for developing and then explaining individualized pet healthcare to the pet owner. Definition and Utilization of Life Stages Puppy From birth through cessation of rapid growth (approximately 6-9 months of age, varying with breed and size) Young adult From cessation of rapid growth until completion of physical and social maturation, which occurs in most dogs by 3 to 4 years of age Mature adult From completion of physical and social maturation until the last 25% of estimated lifespan (breed and size-dependent) Senior the last 25% of estimated lifespan through end of life End-of-life the terminal stage (length of time depends on the specific pathologies) Physiological and behavioral developmental periods do not start and end abruptly, but phase in and out gradually. Team members should acknowledge the differences in life stages, and adapt the experience at the veterinary hospital to each life stage. Client communication regarding potential hazards will reduce these risks, especially for new dog owners or new dogs at any life stage. This extends to discussions on registration and identification of the dog, and long term planning for care. Nutritional Assessment Nutritional assessment, including evaluation of the body/muscle condition score and nutritional factors, should be a part of every visit to the veterinary practice and should utilize the entire practice team.

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Tightness in the legs medicine 014 discount quetiapine uk, which appeared early in the course of recovery for six of the more severe cases treatment zone guiseley purchase quetiapine online now, was replaced by muscle cramps medications jaundice quetiapine 300 mg with mastercard, which persisted up until the last clinical visit 4 years after the onset of neuropathy medicine lux 200 mg quetiapine with mastercard. Two of the six also had hyperreflexia and residual muscle atrophy in the lower extremities, and one had only residual atrophy. The inability of two of the subjects to perceive colors correctly (dyschromatopsia) persisted until the end of the study. In addition, Chang (1991) documented the electrophysiological performance of the 11 cases from their initial diagnosis to complete recovery of motor nerve capacity. However, the nerve conduction velocity of motor nerves remained significantly lower than 36 normal values even when the patients had apparently made a complete recovery (Table 4-4). Subjects typically worked 12 hours/day, 6 days/week, and used a solvent-soaked cloth or sponge to manually clean the printer roller blanket surface 2 to 3 times each hour. They did not wear respirators, but all except four workers wore latex gloves when performing this cleaning operation. The findings from the neurological examination of these workers were compared with the neurological findings of 20 age and gender-matched unexposed controls. Among the 56 printers, 10 were asymptomatic and showed no clinical findings (classified as healthy workers); 26 were asymptomatic, but had subclinical nerve conduction deficits (classified as subclinical workers); and 20 were symptomatic for peripheral neuropathy by clinical and electrophysical findings (classified as symptomatic workers). No relationship was observed between length of employment and the development of neuropathy. Workers that were symptomatic reported experiencing symptoms in the upper and lower extremities such as numbness (8/20 and 14/20, respectively), paraesthesia (5/20 and 13/20, respectively), pain (2/20 and 9/20, respectively), and weakness (7/20 and 15/20, respectively) of the feet and distal portion of the legs. Subjects in the symptomatic group had more severe symptoms in the lower than the upper limbs, and sensory disturbances usually appeared before motor disturbances. Four workers who did not use gloves when cleaning the roller blanket showed symptoms in the upper limbs first. Clinical symptoms were not reported for healthy workers or for those who were asymptomatic, but classified as having subclinical neuropathy. The authors also measured electrophysical deficits in each group of workers (Table 4-5). The highest recorded n-hexane levels in the two factories where the workers were exposed ranged from 2000 to 3250 ppm. In both factories, exposure was to technical grade hexane, which contains other aliphatic hydrocarbons with no known neurotoxic effects. An earlier study by the same researchers described visual defects in this same group of 15 workers, 12 of whom displayed impaired color vision (Raitta et al. The other cases of color vision impairment were acquired, mostly in the blue-yellow axis. In 11/15 subjects there was evidence of associated maculopathy (damage of vessels in eye that leak fluid into the center of the retina causing loss of central vision), in most cases characterized by pigment dispersion. The workers had been exposed to n-hexane in the leather industry (exposure concentration not stated), and all complained of asthenia of upper and lower limbs, paraesthesia in hands and arms, and difficulty walking. All study subjects were free of any visual disorder or inherited color vision impairment. Color vision defects did not show specificity for the blue-yellow or red-green axes but appeared to be distributed across the entire range of color vision deficits. The study involved five workers who had developed peripheral neuropathy as a result of being exposed to n-hexane in a press proofing factory. The subjects worked without protection in a poorly ventilated room and were exposed to three types of solvent mixtures, one of which contained 65% n-hexane. Two 1-hour air samples collected from the work room showed ambient air concentrations of 55 ppm for n-hexane and 9. Four of the five exposed subjects displayed typical signs of neurological impairment, such as muscle cramps, weakness, and distal numbness. In contrast to the fifth (unaffected) subject, these four individuals had slept in the workroom between shifts. As tabulated by the authors, the four most severely affected subjects also displayed such electrophysiological deficits as lower conduction velocities and amplitudes in the median, ulnar, peroneal, and tibial nerves. These workers experienced bodily discomfort and increasing weakness in the lower limbs. Biopsies of the sural nerves revealed axonal swelling and irregular and swollen myelin sheaths. In general, there appeared to have been a dissolution of neurotubules and an increase in the number of microfilaments. Specifically, histopathology and electron microscopy showed polymorphous changes in both myelin sheaths and axons of large diameter fibers of the sural nerve. The authors also observed atrophy and focal degenerative myopathic changes with lymphocytic infiltrates and phagocytosis in the soleus muscle. In one of the subjects, these changes in the muscle appeared to be associated with muscular denervation, lymphocytic infiltrations, and phagocytosis. A follow-up study on the same subjects showed differing severities in the neuropathological responses (Scelsi et al. For example, one of the subjects suffered so 41 much from muscular wasting that she was unable to walk. However, neuropathy in the others was less severe, although symptoms were sufficient for a diagnosis of motor polyneuropathy. Electrophysiological measurements showed motor and sensory conduction velocities to be reduced. Light and electron microscopy of the sural nerve showed the presence of large diameter, irregularly shaped myelinated fibers, degenerated myelin, vacuoles, and abnormal organelles in two of the subjects. A single air sample taken in the middle of the workroom showed the n-hexane concentration to be 195 ppm. All three workers developed progressive muscular weakness, with numbness and tingling sensations in the lower extremities. Their status progressed to the extent of work disability with difficulty walking or holding tools. Values were obtained in two patients that fluctuated below the lower limit of normal as determined in 11 male subjects who had no history of exposure to chemicals. A sural nerve biopsy was obtained from one of the patients 10 weeks after cessation of exposure and showed degeneration of myelinated nerve fibers and paranodal swelling. Electrophysiological deficits with subsequent recovery upon removal of subjects from n-hexane exposure were also demonstrated in four workers who had been exposed to n-hexane during the course of their work at a ball-manufacturing plant in Taiwan (Huang et al. The main source of exposure was solvent evaporation from a cement coating and nylon fiber winding facility. The four workers displayed overt symptoms of peripheral neuropathy and showed electrophysiological deficits in motor conduction of the median, ulnar, peroneal, and tibial nerves. Forty-four workers were interviewed and classified according to their potential exposure to solvents. All subjects were administered a questionnaire detailing personal history and describing subjective symptoms. Electrophysiological determinations of nerve conduction and latencies, and electromyographic measurements were compared with those of 26 age and sex-matched controls. Personal air monitoring samples gave values of 109 ppm n-hexane in the cement coating section (two samples), 86. In motor nerve conduction studies, decreased nerve conduction velocity, prolonged distal latency, and reduced evoked nerve potential were observed in all four nerves studied. Workers in Group I had more severe neurological symptoms, consistent with exposure to higher n-hexane concentrations in the cement coating and nylon fiber winding sections. The factory owner installed a new ventilation system and enclosed portions of the organic solvent operations. There were no new cases of polyneuropathy in a 2-year follow-up at the factory, and all seven originally affected subjects recovered.

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