William J. Fulkerson, MD

  • Professor of Medicine

https://medicine.duke.edu/faculty/william-j-fulkerson-md

Results from these studies are discussed in this section gastritis diet cookbook buy imodium without a prescription, as well as in Section 3 gastritis symptoms medscape order 2mg imodium visa. A slight erythematous response and slight exfoliation were the only observed effects gastritis symptoms and chest pain cheap imodium online visa. No additional information was reported on the design and results of this acnegenesis study gastritis symptoms treatment discount imodium 2mg without a prescription. The eyes were examined for irritation after 24, 48, and 72 hours and 7 days and corneal injury after 72 hours. Multivariate logistic regression analysis of several risk factors showed that only history of engaging in dismantling electronic waste was a significant predictor of micronuclei frequencies. These metabolites would result from oxidation of hydroxylated metabolites to dihydroxylated metabolites by microsomal cytochrome P450s. Based on liver, carcass, and unrecovered concentrations of congeners, and assuming that excretion in the urine was negligible, absorption is estimated to have been 44. Based on liver, carcass, and unrecovered concentrations of congeners, and assuming that excretion in the urine was negligible, absorption is estimated to have been 84. An oral absorption efficiency estimate of about 9% is indicated, assuming that fecal radioactivity excreted in 24 hours was nonabsorbed, and fecal radioactivity excreted between 24 and 72 hours was from biliary excretion of absorbed material. In the second study, rats were exposed to dietary concentrations of 277 or 48,000 ppm (≈20 or 4,300 mg/kg/day). For both dose levels, the percent of 14C dose remaining in the gut contents (<4%) and gut tissue (<0. The radioactivity in bile indicates that at least 10% of the dose was absorbed (Morck and Klasson Wehler 2001; Morck et al. This finding indicates an absorption efficiency of about 20%, assuming that radioactivity recovered in the feces (about 66% of the administered dose) was not absorbed. Approximately 5% of the dose in rats and 7% of the dose in mice was excreted as parent congener in the feces in 24 hours. Assuming that radioactivity excreted in feces within 24 hours was non-absorbed, reported values of 11. Profiles of radioactivity in urine, feces, and tissues 5 days after dermal or intravenous administration were compared to estimate dermal absorption efficiency. Approximately 15% of the administered dose remained at the site of application 5 days after application. Transfer of radioactivity to the receptor fluid was minimal, accounting for only 0. The highest percentage of the dose in the skin was associated with application of the lowest dose. Washing the skin with solvent 24 hours after application removed 77–92% of the applied dose. At necropsy, sections of the lungs, adipose tissue, and liver were collected for bromine analysis using a neutron activation technique. The results showed concentrations of bromine in the lungs and adipose tissue significantly higher in all groups relative to controls; the amounts of bromine detected were concentration-related. In the liver, the concentration of bromine was also elevated in all groups relative to controls except in the 1. In both maternal and cord serum samples, the congeners with the highest geometric mean concentrations (ranging from 3. Placentas were perfused for 4 hours with 1 ng/mL concentrations of the non-labeled congeners. The detection of higher­ brominated congeners in some of these recent studies indicates that both lower and higher-brominated congeners can be distributed to breast milk (Antignac et al. On day 16 after dosing, radioactivity was only detected in adrenals and spleen (0. A similar order was observed in female rats, but the amount of radioactivity in adipose in females (37%) was higher than in male rats (24. Using percent of dose/g of tissue as the dose metric to compare single-dose levels in rats reported by Staskal et al. Similar orders of tissue concentrations were seen 24 hours after oral administration in male rats given single 1, 10, 100, or 1,000 µmol/kg doses, and in female F344 rats and male and female B6C3F1 mice given single 1 µmol/kg doses (Chen et al. Preferential accumulation in adipose also was found in male Sprague-Dawley rats 24 hours after administration of 14. This observation suggests that adipose and skin serve as sinks for radioactivity initially distributed to other tissues. Expression of the data on a concentration basis (nmol 14C equivalents/g wet tissue weight) showed the highest concentrations in lipid rich tissues: adrenals (29. Information from in vivo toxicokinetic studies with rodents exposed to the best studied congeners. Structures of other metabolites were determined with authentic chemical standards and ultra- performance liquid chromatography-mass spectrometry techniques. Structures of other metabolites were determined with authentic chemical standards and ultra-performance liquid chromatography-mass spectrometry techniques. Studies with bile duct-cannulated male rats indicated that radioactivity excreted in feces of conventional rats included bile duct-delivered metabolites. Ratios of cumulative percentage dose excreted as parent compound or metabolite in urine were 1. These models are biologically and mechanistically based and can be used to extrapolate the pharmacokinetic behavior of chemical substances from high to low dose, from route to route, between species, and between subpopulations within a species. Solving these differential and algebraic equations provides the predictions of tissue dose. If the uptake and disposition of the chemical substance(s) are adequately described, however, this simplification is desirable because data are often unavailable for many biological processes. The model included eight compartments: liver, brain, adipose tissue, kidney, placenta, fetus, blood, and the remaining body. The model was calibrated with tissue concentration data from adult male and maternal-fetal toxicokinetic studies. The chemical substance is shown to be absorbed via the skin, by inhalation, or by ingestion, metabolized in the liver, and excreted in the urine or by exhalation. Bioavailability was also increased with increasing carbohydrate content, potentially due to the formation of micelles (Yu et al. Placentas were perfused for 4 hours with 1 ng/mL concentrations of the nonlabeled congeners. Information from in vivo toxicokinetic studies with rodents exposed to the best studied congeners. Other potential targets are the female reproductive system, the adult nervous system, and the developing and adult immune system; however, evidence for these end points is limited. For other effects, including reproductive toxicity, immunotoxicity, and hepatotoxicity, only limited mechanistic data are available. In particular, the oxygen bridge of the ether linkage in the diphenyl ether molecule increases the distance between the biphenyl rings, introduces a 120° bend in the alignment of the biphenyl rings, and serves as a barrier to rotation that inhibits the two aromatic rings from assuming a coplanar configuration (Hardy 2002a; Howie et al. Furthermore, halogen substitution of the ortho positions in the diphenylether molecule, as occurs for some congeners, pushes the aromatic rings to be orthoganol to each other. The researchers speculated that the large size of the bromine atoms may distort the AhR binding site so that coplanar configuration is not required. This has implications not only for dioxin-type toxicities, which are mediated by the AhR pathway, but also for non-dioxin-type effects. These differences contribute to dissimilar physical/chemical properties that can influence the relative bioavailability, absorption, tissue accumulation, receptor interactions, and toxicities of the chemicals. Possible explanations for this effect included the increased polarizability of bromine versus chlorine and differences in the electronic, hydrophobic, and hydrogen bonding characteristics of bromine and chlorine (Andres et al. Seven of the congeners showed luciferase expression, indicating their ability to activate the AhR. This would serve to increase the number of occupied sites on T4-binding proteins and subsequently result in decreased serum levels of T4; however, this mechanism is not fully elucidated. These congeners were tested because they theoretically show the highest structural similarity to T4 and T3. None of the hydroxylated derivatives effectively competed with the thyroid hormones for binding to either receptor (affinities were 41–>1,000 times less than for T4 and T3).

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In some cases gastritis alcohol buy 2mg imodium fast delivery, however treating gastritis diet generic imodium 2 mg without prescription, the external sphincter remains closed gastritis supplements cheap imodium 2mg with amex, and the dangerous increase in detrusor pressure persists gastritis diet 5 small discount imodium 2mg online. In such patients a deliberate incision of the external sphincter may be necessary so that the bladder will become incontinent, and the patient voids without any increase in pressure into a condom urinal. A number of instruments are now available for crushing bladder calculi including the optical lithotrite (Fig. These optical instruments are ideal for small calculi, and allow the stone to be broken up under vision and evacuated with an Ellik evacuator (Fig. Larger stones can be fragmented by a combination of electrohydraulic lithotripsy and the Mauermayer stone punch. When there has been a large stone that has been present for a long time it is prudent to take a mucosal biopsy of any suspicious area in view of the occasional complication of 12 squamous cell cancer. It is then more convenient to resect most of the middle lobe, then crush and evacuate the stone, and complete the transurethral resection in the usual way. Diverticula of the bladder Small saccules are commonly present in association with prostatic obstruction and can be disregarded (Fig. Larger diverticula must always be fully examined by passing the cystoscope inside them to rule out cancer or a stone; be particularly suspicious of a diverticulum whose opening is oedematous or inflamed. When it harbours a stone or a tumour, or when there is continuing infection, the diverticulum should be removed, but since the prostate is often quite a small one, it is easier to perform the prostatectomy transurethrally and then go on to do the diverticulectomy in the usual 13 way. Urethral strictures and transnrethral resection Strictures may be found in patients who need transurethral resection of a bladder tumour. To allow the passage of the resectoscope it is necessary to dilate them or perform an optical urethrotomy. Urethrotomy by itself does not Carcinoma and other disorders of the prostate and bladder 165 Figure 8. When there is a bladder tumour to be resected prudence suggests that dilatation may be preferable in view of the possible implantation of cancer cells into the raw area in the urethra, although such cases must be exceedingly rare. Correlation of ultrasound guided and digitally directed biopsies of palpable prostatic abnormalities. The risk of distant metastases after transurethral resection of the prostate versus needle biopsy in patients with localized prostate cancer. The influence of transurethral resection of prostate on prognosis of patients with adenocarcinoma of the prostate treated by radical radiotherapy. Calcifications in the prostate gland and adjacent tissues: a combined biophysical and histological study. Sphincterotomy and the treatment of detrusor- sphincter dyssynergia: current status, future prospects. Dilatation versus internal urethrotomy as out-patient treatment for male urethral stricture—a prospective, randomized clinical trial. Chapter 9 Routine postoperative care after transurethral resection In the recovery room From the operating table the patient goes to the recovery room where, in addition to monitoring the usual vital signs, the airway and the intravenous drip (if there is one), the nursing team pay particular attention to the three-way catheter and its irrigating system (Fig. The penile swab used for tamponade is removed before the patient returns to the ward. Routine postoperative care after transurethral resection 169 It is a sensible idea to get to know your recovery room staff. Spend a few moments telling them what operation you have done, and what problems you anticipate. Try to become actively involved in teaching the young recovery nurse about how you like the patient to be managed in the recovery room. Listen to the opinions of the nurses and avoid dismissing their suggestions in what may appear to be an arrogant fashion. It is a good idea to pass through the recovery room from time to time to check that all is well with the patients you have operated on. You might identify problems at an early stage when they are easier to correct and at the very least you will gain a reputation as a surgeon who takes an active interest in the postoperative care of your patients. If necessary, intravenous fluids and a diuretic are given to encourage an adequate output of urine. The authors mistrust this system, fearing that it courts the risk of dilutional hyponatraemia, particularly in a patient with an inappropriate secretion of antidiuretic hormone, but it has some advocates. Some surgeons prefer to leave the catheter to drain freely, only irrigating it with a hand syringe if the flow is blocked. The disadvantage of this method is the risk of 1 introducing infection whenever the bladder is irrigated with a syringe. In the usual technique with the three-way catheter the purpose of the irrigation is to dilute the blood so that a clot will not form to block the catheter. The rate of inflow of the saline is adjusted from time to time to keep the outflow a pale pink vin rosé colour, and as a rule the rate of inflow can be cut down after about 20 minutes. Get into the habit of emptying the bag just before the patient leaves the operating theatre and of reviewing the patient in the recovery room from time to time to check that the catheter bag is not being neglected and allowed to overfill. In both these latter cases the first thing is to apply a bladder syringe to the end of the catheter and give it a good suck: this will often start the flow. If not, some of the irrigant should be drawn up in the syringe until it is about half-full, and about 20 ml injected before smartly aspirating again with the object of clearing the eye of the catheter. The offending chip of prostate may declare itself stuck in the eyeholes in the end of the catheter. Place a curved introducer in a new catheter and take care not to catch the bladder neck as you introduce it. More or less clear urine usually runs out at once, and when the bladder is empty irrigation can be started again. If the bladder has been allowed to become full of clot then the patient should be returned to the theatre without delay. This is one of the chief advantages of having the recovery room close to the operating theatre: a message from the recovery room nurse will bring one of the surgical team within seconds, who can check the situation and make the decision to return the patient or not without delay. Experienced nursing staff usually know when it is time to return the patient and the young surgeon does well to take heed of their advice. It is far better to err on the side of caution than waste valuable time, while the patient may be continuing to bleed, fiddling with a bladder syringe and a hopelessly blocked catheter. Routine postoperative care after transurethral resection 171 Clot evacuation Once re-anaesthetized the patient is repositioned, cleaned and draped as for a transurethral resection. Often this will allow a clot or chip to emerge and the problem is solved, but it is always wise to look into the bladder and irrigate out any clots that may be there with the Ellik evacuator (Fig. When the bladder has been emptied, check the cavity of the prostate for any source of bleeding. It is rare that you will find any: the bleeding (as with the tonsil bed) has usually stopped when the clot has been evacuated. Rarely you may find a little tag of prostate which seems to be keeping a small vein open: resect it and coagulate the vein. The resectoscope sheath is passed and the Ellik evacuator is used to break up the clot and suck it out. Very occasionally there may appear to be normal flow of urine into and out of the bladder, the urine may be only lightly blood-stained, but the patient may complain that their bladder feels full. The distended bladder suggests that the catheter is blocked, but this does not fit with the apparently normal flow of irrigant through the drainage system. Irrigant simply passes out from the irrigation channel at the tip of the catheter and then directly back out of the bladder again through the outflow channel of the catheter. Attempts at evacuation of the thick clot through the catheter using a bladder syringe will not work. The only way to deal with this is to take the patient back to theatre, evacuate the clot from the bladder and find and control the source of the persistent bleeding. Major reactionary haemorrhage Mercifully very rare, major reactionary haemorrhage may take place without warning. If there is time, and the general condition of the patient permits, the bladder should be emptied with the Ellik and the source of bleeding coagulated, if possible, or controlled by traction on the Foley catheter. Exceptionally, the bleeding is impossible to control by these means, and it is necessary to open the patient and pack the prostate bed. Routine postoperative care after transurethral resection 173 the retropubic space is opened through a Pfannenstiel incision. Allow plenty of time for loss of blood to be restored, and then remove the pack, try to identify the source of bleeding, and suture the offending vessel.

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To learn more gastritis icd 9 order imodium american express, and get the most updated disease and treatment information alcoholic gastritis definition discount 2 mg imodium free shipping, visit Background: recent studies have recommended incision and drainage alone for simple abscess – Singer et al gastritis diet 7 day buy generic imodium 2 mg line. Topical clotrimazole Department of Dermatology Evaluating the need for laboratory testing in the treatment of onychomycosis gastritis symptoms nih generic imodium 2 mg visa. Empirical treatment with terbinafine is more cost effective than confirmatory testing with minimal effect on patient safety. Confirmatory testing before treatment with efinaconazole 10% is associated with reduced costs Department of Dermatology Onychomycosis treatment. Treat with pulse fluconazole 200mg weekly x 3-9 months – Cost for terbinafine and fluconazole is low – Cost of efinaconazole is high (cure rates 15%). Significant liver injury is uncommon and most resolve with discontinuation of the drug. Need to reconsider need for extensive lab testing for derm drugs like pulse anti fungal therapy, isotretinoin, spironolactone and others Department of Dermatology Presentation of case. Randomized trial of calcipotriol combined with 5- fluorouracil for skin cancer precursor immunotherapy. The expanded board will ensure that we are able to review manuscripts in a timely and efficient way. We are confident that this will serve to improve the quality of our journal and also make the journal more uniform and consistent in format and content. As always, we would like to increase the number of members that sit on our editorial board. Beginning with the next issue, all editorial-board members will have their photos in the front of the journal. If any reader has questions or issues with any of the manuscript that appears in this issue, they should contact the author and/or their program chairman directly. The sap of this plant consists of calcium oxalate crystals, acrid oils, saponins, and other compounds. Previous case reports have demonstrated a contact reaction to this plant sap with both skin and systemic symptoms. A vesiculopapular and purpuric variant has been described with and without systemic manifestations. Clinical purpuric lesions were also shown to have a leukocytoclastic vasculitis upon histologic exam. This case report provides clinical demonstration of a purpuric variant with concomitant systemic symp- toms soon after exposure to the sap of this plant. Key words: agave americana; century plant; vasculitis; contact dermatitis; irritant contact dermatitis; systemic symptoms Case Report Discussion another purpuric variant with systemic symptoms, it has been speculated that A 63-year-old male presented with Agave Americana, also known as the the oxalic acid crystals lead to localized and systemic vascular damage. He also member of the Agaveceae family that forms to have a contact dermatitis provoked by Agave americana. It gets the name Century this case represents another appetite, myalgia, eyelid swelling, and an plant from its infrequent, exuberant vesiculopapular vasculitic variant with overall feeling of malaise. As in the afterward, the patient went into his pool once every 100 years, but in reality the purpuric variants described, a chainsaw and then took a shower with soap in an plant flowers after 25 years and then dies. The next day, red papules variety of commercial (rope, fibers, mescal, transmitted to the skin. This author and vesicles began to appear, and then tequila), medicinal (steroid extraction, agrees that the oxalic acid crystals may excoriations began to appear secondary to pre-Columbian antibacterial salves), and be a culprit in causing localized and the scratching. Contact Physical exam revealed excoriated hormones) are the source of the marked Dermatitis 1995; 33:60-1. Irritant contact dermati- erythematous papules and vesicles on pruritus and stinging associated with this from Agave americana L. Incorrect use of sap as hair both legs and arms sparing the clothing- exposure to the sap of the Agave plant. There were scattered, bright Oxalic acid poisoning may lead to acidosis, agave dermatitis. Cutis 2000:66: Our clinical diagnosis was a vasculitic or mediators of inflammation released 287-8. A follow-up visit at seven evidence of leukocytoclastic vasculitis days revealed a complete resolution of the and a lack of systemic symptoms, has lesions with only a slight superficial scaling demonstrated a localized cutaneous vasculitis on histologic exam. Figure 4: Agave Americana: Example of exuberant flowering that consists of a spike with cyme of big yellow flowers that arises from a central stem. Figure 3: Agave americana, also known as the Century plant, in non-flowering state. We present a unique case of Muir-Torre syndrome with angiosarcoma in addition to colon and renal carcinoma. This study revealed the dermatology office for evaluation of a adenoma with an architectural pattern or that 42 percent of patients with one or few flesh-colored papules in the head and combined features of keratoacanthoma. The patient was are benign, sebaceous proliferations in 6 percent of cases, and to present clinically described as solitary, yellowish afterwards in 56 percent of cases. Later in 2004, another lesion along the right nasal crease papules with rolled borders and the skin lesion might be a harbinger for an was biopsied and revealed sebaceous measuring <1 cm in diameter, but larger internal malignancy. The median age of onset is 55 years, malignancy, warranting an investigation for cancer in the family history for a the internal malignancies associated with with a male-to-female ratio of 3:2. Furthermore, screening for women to an altered amino-acid sequence and a between the ages of 25 and 30 should false-negative result. They may vary in size but identify other affected family members is are typically the same length within also recommended. Microsatellites are susceptible to mutations, and when the mutations are References not repaired they can become abnormally short or long. Mismatch repair proteins expression and microsatellite instability in skin although these included a smaller number lesions with sebaceous differentiation: a study in different of patients. Muir Torre syndrome: a case for 0-32% of spontaneous sebaceous lesions surveillance of the ampulla of Vater. Mangold E, Rahner N, Friedrichs N, Buettner R, Summary Pagenstecher C, Aretz S, et al. Screening for Lynch syndrome history, which would have been helpful (hereditary nonpolyposis colorectal cancer). She but can appear anywhere, including the also had negative blood and strep cultures. She also complained of sore throat, wrist pain, disease was made, and she was admitted to Arthritis with wrist involvement may abdominal pain with nausea and vomiting, the inpatient medical service. Previous workup had not is a rare systemic disorder of unknown been reported with the proximal and distal revealed any infectious process. Other signs and no previous surgeries and reported no the condition mimics infectious (viral or symptoms include myalgias, sore throat, medication allergies. Her family history bacterial) diseases and rheumatological lymphadenopathy, splenomegaly, pleuritis, included type 2 diabetes mellitus, heart conditions, and may present similar pericarditis, and abdominal pain (maybe due to mesenteric lymphadenitis). She admitted to to malignancies such as leukemia and smoking 3-4 cigarettes per day. She had a generalized, erythrocyte sedimentation rate, C-reactive may be used to monitor disease activity macular and papular rash showing protein, and serum ferritin levels have also and assess treatment efficacy (levels fall as 2 symptoms are relieved). Her disease has now progressed, and she has required treatment with methotrexate and adalimumab (Humira). Her disease course is consistent with the chronic articular pattern described above. Her metaplasia, and focal mild inflammation, abdomen was tender to palpation in the but no Helicobacter were seen by A 43-year-old Caucasian female mid-epigastric region. She had A colonoscopy with biopsies had been abdominal pain associated with anorexia, synovitis in the ankles and bilateral performed six months earlier. The left constipation, and bloating of one-month swelling of the hands with joint colon was significant for numerous isolated duration. Multiple papillary lesions ulcerations with areas of inflammation and pain in her ankles, hands, and lower with scabs less than 1 centimeter were with edema, and multiple ulcerations were back. The patient is well known to us, noted on her chin, and hypopigmented noted as the scope was advanced (Images). She reported having flares elevated erythrocyte sedimentation rate patchy colitis with multiple ulcerations of her typically abdominal symptoms of 77, C-reactive protein of 11. In addition to the pain and bloating, normocytic, normochromic anemia with Colon-biopsy reports revealed she also sometimes experienced severe a hemoglobin level of 9. The duodenum showed mild the medication secondary to financial Her past surgical history includes inflammation, but no ulceration.

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The text makes occasional reference to electrical units; however gastritis and duodenitis definition purchase discount imodium online, these are conventional and do not have coun- terparts in the English system gastritis diet purchase imodium online now, so no electrical units are discussed here diet by gastritis order imodium 2 mg on line. We present conversion factors in the form of multipliers that may be applied to English units so as to obtain S gastritis diet imodium 2 mg with visa. Like the Btu, the calorie has several values that depend on the initial temperature of the water warmed. A, Ac,Ah,Aj volume (J/kg·K) area (m2) or function defined c molar concentration of a in eqn. F, 444 Biot number, 24 Boundary conditions, 70, 134–135 for fins, 157–160 Boundary layers, 19, 255–310 for lumped capacity behavior, 24 Blasius solution, 268–272 Biot, J. Blowing, 598 effect of Pr, 285–286, 290 Blowing factor, 598 forced convection, 278–297 Boiling, 421–469 natural convection, 364–382 Forced convection boiling, thickness, 290 457–466 relation to transient conduction, in external flows, 457–460 213 in tubes, 460–466 turbulent b. System, 14, 663–667 turbulent Prandtl number, 304 Samurai sword, 208–209 Prandtl, L. Psychrometer, sling, 611 Macbeth, 421 Pumping power, 120 Venus and Adonis, 487 Sherwood number, 600 Sherwood, T. Strutt), 143 Solar energy, 530–535 Reactions solar collectors, 534–535 heterogeneous, 556, 576, 615, wavelength distribution, 491 617, 625 Solubility, 580 homogeneous, 576, 615 Soret effect, 562, 618 Reflectance, 29 Species conservation, 576–586 Subject Index 687 boundary conditions for, 579–582 Thermal diffusion, 562 equation of, 576–579 Thermal diffusivity, 19 for stationary media, 582–585 Thermal expansion, coefficient of, 367 for steady state, 585–586 for an ideal gas, 369 Species-average velocity, 553 Thermal radiation, 26–34, 487–535 Specific heat capacity, 18, 278 black body, 28–32 for mixtures, 576 black body exchange, 499–511 Specific heat ratio, 573 diffuse and specular, 492–493 Speed of light in vacuum, 32, 661 gaseous, see Gaseous radiation Stagnant film model, 597–598, 623 gray body, 489 Stanton number, 298 gray body exchange, 495–497 Stefan tube, 586 algebraic solutions, 519–522 Stefan, J. All notices and other communications between the parties and related to this agreement will be in writing. For clarity, writing contained in electronic mail is acceptable for the purposes of this section. The limitations of this section shall apply whether or not the alleged breach or default is a breach of a fundamental condition or term. This agreement constitutes the entire agreement between the parties with respect to its subject matter. Sections 5, 6, 16, 21, 23, 24, and 31 survive the termination or expiration of this agreement and continue in full force and effect. If any provision (in whole or in part) of this agreement is deemed void, invalid, illegal or unenforceable by a court or other lawful authority, the agreement will continue in force with the void, invalid, illegal or unenforceable provision eliminated. This agreement may only be amended by the mutual agreement of the parties in writing. This agreement will be governed by and construed in accordance with the laws in force in the Canadian province of Ontario without regard to its conflicts-of-laws provisions. The Licensee agrees and acknowledges that any dispute arising in connection with this agreement will be settled by the courts in Ottawa, Ontario, Canada. Modified by permission for Canadian Government purposes, by the Canadian Institute for Health Information. It is possible to perform analysis on health interventions looking at just one or any combination of the "components". This makes the classification into a very flexible and powerful tool for searching and organizing information about healthcare interventions. This means that the same field 4 code "component", for example, can be used to mean different things in different sections. While attempts have been made to ensure that certain concepts that are repeated in the different sections retain the same code component value and meaning, it would be impossible in a ten-digit code string to enforce unique "component" descriptions across all the sections. This would inhibit the potential for future code "component" expansion when it is anticipated that there will be considerable future demand for "room for growth" to incorporate more detail in the code "components" as the techniques for performing health interventions change. In particular fields 4, 5 and 6 represent the dynamic aspect of "how" the intervention is performed and can be expected to change greatly over time. Section: the first character (field 1) of each code represents the broad realm of intervention. There are currently seven choices: 1: Physical and physiological therapeutic interventions 2: Other diagnostic interventions 3: Diagnostic imaging interventions 5: Obstetrical and fetal interventions 6: Cognitive, psychosocial and sensory therapeutic interventions 7: Other healthcare interventions 8: Therapeutic interventions strengthening the immune system and/or genetic composition A healthcare intervention may fall into only one of these "sections". A decision tree was used as an arbitrary method to impose logic on the assignment of interventions to sections in order to enforce a basic classification rule - uniqueness of code concept. In three of the sections this is anatomy site while in others it is mental/sensory function or stage of pregnancy. Intervention: the fourth and fifth characters (field 3) always represent generic types of healthcare actions. The two-digit code "component" has unique meaning when it is linked with the section code "component". As mentioned previously, the meaning of field 2,3, 4, 5 and 6 are section-dependent. Qualifier 1: the sixth and seventh characters (field 4) represent the first intervention qualifier describing how (or why) it was completed. In other sections, such as section 1, it represents only a part of the qualifier - the approach and technique portion. Definitions of Common Surgical Approaches: Open approach: usually implies that an incision was made to gain access to the site but there are some exceptions to this. For example, excision of the tonsils and adenoids is considered an open approach but no incision is made to gain access. As was the case in other classifications, the entry and closure are inherent in the code and are not coded separately. If the closure does not require tissue, a different qualifier may be selected to portray this fact. Endoscopic approach: includes interventions done via the laparoscope, thoracoscope, hysteroscope, and so on. Incisions are minimal in size and are often referred to as ports or as a minimally invasive technique. Endoscopic per orifice approach: includes interventions done via the cystoscope, bronchoscope, etc. The scope is inserted via an orifice (natural orifice or one surgically created) and no incision is required. Per orifice approach: includes those interventions that are done through an existing orifice but without a scope or incision. Percutaneous approach: includes those interventions that are done through a needle, large bore needle or catheter. Examples include angioplasties, removal or a ureteral calculus via a nephrostomy tube. External approach: includes those interventions done on the outside of the body that do not require an incision, scope or needle to gain access to the site. Qualifier 2: the eighth and ninth characters (field 5) represent the second intervention qualifier describing the tools, agents or modalities used. Qualifier 3: the tenth character (field 6) represents the third and final intervention qualifier. Currently, this qualifier has been activated for use in section 1 only to describe the use of tissue (human, animal or synthetic) during an intervention. Apheresis technique for procurement of healthy blood components for later transfusion is classified to Procurement. Brachytherapy (26) Implanting radioactive material within a body site to destroy tissue over time. Mobilization (04) Moving a joint (or soft tissue) within the physiological range of motion without a high velocity thrust. Natural remedy (15) Provision of a specific combination of natural elements (such as flowers, herbs or plants in tea, tincture or capsule form) to holistically restore balance and energy to the body. May also include ordering diagnostic investigations, reviewing results, prescribing and counseling as appropriate. Excludes the collection of body fluid (see Specimen collection) Excludes excisional biopsy where the intent is also to remove a lesion or body part (see Excision, partial in Section 1). Needle biopsy Capacity measurement (21) Determining the power or ability of a body part/organ to hold, retain, contain or absorb. In cardiac testing, it involves the graphic representation of heart sounds, murmurs, or other acoustic phenomena. Intracardiac phonocardiography is done by passing a phonocatheter into one of the heart chambers. Cardiac phonocatheterization Specimen collection (diagnostic) (13) Obtaining a sample of body fluid for the purposes of diagnostic testing. Urine samples Test (08) An examination or trial of function, production, or range of movement of a body part or system. Also includes those examinations done for the purpose of radiation treatment planning or simulation. Unless stated otherwise, a fluoroscopy examination done as a separate examination or as fluoroscopic control for another intervention should be coded separately using the appropriate code.

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